Published clinical studies

  1. de Azevedo Vieira, A.R.S., Porto-Dantas, L.B., do Prado Romani, F.A. et al. Autonomic neuropathic symptoms in patients with diabetes: practical tools for screening in daily routine Diabetol Metab Syndr 15, 83 (2023).
  2. Mendivil CO, Kattah W, Orduz A, Tique C, Cárdenas JL, Patiño JE. Neuropad for the detection of cardiovascular autonomic neuropathy in patients with type 2 diabetes. J Diabetes Complications. 2015 Oct 14. pii: S1056-8727(15)00394-3. doi: 10.1016/j.jdiacomp.2015.10.004. [Epub ahead of print]
  3. Ponirakis G, Fadavi H, Petropoulos IN, Azmi S, Ferdousi M, Dabbah MA, Kheyami A, Alam U, Asghar O, Marshall A, Tavakoli M, Al-Ahmar A, Javed S, Jeziorska M, Malik RA. Automated quantification of Neuropad improves its diagnostic ability in patients with diabetic neuropathy. J Diabetes Res. 2015;2015:847-54.
  4. Ishibashi F, Kojima R, Kawasaki A, Yamanaka E, Kosaka A, Uetake H. Correlation between sudomotor function, sweat gland duct size and corneal nerve fiber pathology in patients with type 2 diabetes mellitus. J Diabetes Investig. 2014 Sep;5(5):588-96.
  5. Ponirakis G, Petropoulos IN, Fadavi H, Alam U, Asghar O, Marshall A, Tavakoli M, Malik RA. The diagnostic accuracy of Neuropad for assessing large and small fibre diabetic neuropathy.Diabet Med. 2014 Dec;31(12):1673-80.
  6. Papanas N, Ziegler D. New vistas in the diagnosis of diabetic polyneuropathy. Endocrine. 2014 Dec;47(3):690-8. Review.
  7. Qin Y, Cao Y, Gao F, Luo X, Li J, Fu X, Xue Y. Neuropad test for sudomotor function to predict the risk of diabetic foot ulceration Nan Fang Yi Ke Da Xue Xue Bao. 2014 Apr;34(4):560-2. Chinese.
  8. Manes C, Papanas N, Exiara T, Katsiki N, Papantoniou S, Kirlaki E, Tsotoulidis S, Kefalogiannis N, Maltezos E. The indicator test Neuropad in the assessment of small and overall nerve fibre dysfunction in patients with type 2 diabetes: a large multicentre study. Exp Clin Endocrinol Diabetes. 2014 Mar;122(3):195-9.
  9. Tsapas A, Liakos A, Paschos P, Karagiannis T, Bekiari E, Tentolouris N, Boura P. A simple plaster for screening for diabetic neuropathy: a diagnostic test accuracy systematic review and meta-analysis. Metabolism. 2014 Apr;63(4):584-92. Review.
  10. Tomešová J, Gruberova J, Lacigova S, Cechurova D, Jankovec Z, Rusavy Z. Differences in skin microcirculation on the upper and lower extremities in patients with diabetes mellitus: relationship of diabetic neuropathy and skin microcirculation. Diabetes Technol Ther. 2013 Nov;15(11):968-75.`
  11. Karachristianou S, Papamichalis E, Sarantopoulos A, Boura P, Georgiadis G. Hypohidrosis induced by topiramate in an adult patient.Epileptic Disord. 2013 Jun;15(2):203-6.
  12. Aubert CE, Le Doeuff J, Lajou J, Barthelemy O, Hartemann A, Bourron O. Influence of peripheral arterial occlusive disease on the Neuropad test performance in patients with diabetes. Diabet Med. 2013 May;30(5):e178-84.
  13. Papanas N, Boulton AJ, Malik RA, Manes C, Schnell O, Spallone V, Tentolouris N, Tesfaye S, Valensi P, Ziegler D, Kempler P. A simple new non-invasive sweat indicator test for the diagnosis of diabetic neuropathy. Diabet Med. 2013 May;30(5):525-34. Review.
  14. Sanz-Corbalán I, Lázaro-Martínez JL, García-Morales E, Aragón-Sánchez J, Carabantes-Alarcón D, García-Álvarez Y. Relationship of limited joint mobility and foot deformities with neurological examination in patients with diabetes. Exp Clin Endocrinol Diabetes. 2013 Apr;121(4):239-43.
  15. Yoshioka K, Okada H. Useful application of the Neuropad test for assessment of diabetic polyneuropathy. Intern Med. 2012;51(23):3241-5.
  16. Vieru A, Niţă O, Graur LI, Mazilu G, Mihalache L, Popescu RM, Graur M. Neuropad test in evaluation of diabetic foot. Rev Med Chir Soc Med Nat Iasi. 2012 Jan-Mar;116(1):90-6. Romanian.
  17. Ziegler D, Papanas N, Rathmann W, Heier M, Scheer M, Meisinger C; KORA Study Group. Evaluation of the Neuropad sudomotor function test as a screening tool for polyneuropathy in the elderly population with diabetes and pre-diabetes: the KORA F4 survey. Diabetes Metab Res Rev. 2012 Nov;28(8):692-7.
  18. Pritchard N, Edwards K, Vagenas D, Russell AW, Malik RA, Efron N. Corneal sensitivity is related to established measures of diabetic peripheral neuropathy. Clin Exp Optom. 2012 May;95(3):355-61.
  19. Datema M, Gert van Dijk J, Hoitsma E. The diagnostic value of water immersion skin wrinkling and Neuropads in small fiber neuropathy. Clin Neurophysiol. 2012 Oct;123(10):2074-9.
  20. Papanas N, Demetriou M, Katsiki N, Papatheodorou K, Papazoglou D, Gioka T, Kotsiou S, Maltezos E, Mikhailidis DP. Increased serum levels of uric acid are associated with sudomotor dysfunction in subjects with type 2 diabetes mellitus. Exp Diabetes Res. 2011;2011:346051.
  21. Ziegler D, Papanas N, Roden M; GDC Study Group. Neuropad: evaluation of three cut-off points of sudomotor dysfunction for early detection of polyneuropathy in recently diagnosed diabetes. Diabet Med. 2011 Nov;28(11):1412-5
  22. Papanas N, Paschos P, Papazoglou D, Papatheodorou K, Paletas K, Maltezos E, Tsapas A. Accuracy of the Neuropad test for the diagnosis of distal symmetric polyneuropathy in type 2 diabetes. Diabetes Care. 2011 Jun;34(6):1378-82.
  23. Argiana V, Eleftheriadou I, Tentolouris N. Screening for the high-risk foot of ulceration: tests of somatic and autonomic nerve function. Curr Diab Rep. 2011 Aug;11(4):294-301.Review.
  24. Papanas N, Papazoglou D, Papatheodorou K, Maltezos E. Evaluation of a new foam to increase skin hydration of the foot in type 2 diabetes: a pilot study. Int Wound J. 2011 Jun;8(3):297-300.
  25. Papanas N, Papatheodorou K, Papazoglou D, Kotsiou S, Maltezos E. A prospective study on the use of the indicator test Neuropad for the early diagnosis of peripheral neuropathy in type 2 diabetes. Exp Clin Endocrinol Diabetes. 2011 Feb;119(2):122-5.
  1. Papanas N, Papatheodorou K, Papazoglou D, Kotsiou S, Maltezos E. J Association between foot temperature and sudomotor dysfunction in type 2 diabetes. Diabetes Sci Technol. 2010 Jul 1;4(4):803-7.
  2. Kamenov ZA, Petrova JJ, Christov VG. Diagnosis of diabetic neuropathy using simple somatic and a new autonomic (Neuropad) tests in the clinical practice. Exp Clin Endocrinol Diabetes. 2010 Apr;118(4):226-33.
  3. Freitas C, Carvalho A, Melo-Rocha G, Amaral C, Pinto S, Guimarães R, Neto H, Suascun J, Muras J, Gonçalves I, Martins J, Dores J, Carvalho R, Borges F. The Neuropadtest in the screening of peripheral neuropathy in diabetic patients. Acta Med Port. 2009 Nov-Dec;22(6):729-34. Portuguese.
  4. Papanas N, Ziegler D. J New diagnostic tests for diabetic distal symmetric polyneuropathy. Diabetes Complications. 2011 Jan-Feb;25(1):44-51.
  5. Tentolouris N, Voulgari C, Liatis S, Kokkinos A, Eleftheriadou I, Makrilakis K, Marinou K, Katsilambros N. Moisture status of the skin of the feet assessed by the visual test Neuropad correlates with foot ulceration in diabetes. Diabetes Care. 2010 May;33(5):1112-4.
  6. Spallone V, Morganti R, Siampli M, Fedele T, D’Amato C, Cacciotti L, Maiello MR. Neuropadas a diagnostic tool for diabetic autonomic and sensorimotor neuropathy. Diabet Med. 2009 Jul;26(7):686-92.
  7. Quattrini C, Jeziorska M, Tavakoli M, Begum P, Boulton AJ, Malik RA. The Neuropad test: a visual indicator test for human diabetic neuropathy. Diabetologia. 2008 Jun;51(6):1046-50.
  8. Papanas N, Papatheodorou K, Papazoglou D, Monastiriotis C, Christakidis D, Maltezos E. A comparison of the new indicator test for sudomotor function (Neuropad) with the vibration perception threshold and the clinical examination in the diagnosis of peripheral neuropathy in subjects with type 2 diabetes. Exp Clin Endocrinol Diabetes. 2008 Feb;116(2):135-8.
  9. Tentolouris N, Achtsidis V, Marinou K, Katsilambros N. Evaluation of the self-administered indicator plaster Neuropad for the diagnosis of neuropathy in diabetes.Diabetes Care. 2008 Feb;31(2):236-7.
  10. Bilen H, Atmaca A, Akcay G. Neuropad indicator test for diagnosis of sudomotor dysfunction in type 2 diabetes. Adv Ther. 2007 Sep-Oct;24(5):1020-7.
  11. Papanas N, Giassakis G, Papatheodorou K, Papazoglou D, Monastiriotis C, Christakidis D, Piperidou H, Maltezos E. J Sensitivity and specificity of a new indicator test (Neuropad) for the diagnosis of peripheral neuropathy in type 2 diabetes patients: a comparison with clinical examination and nerve conduction study. Diabetes Complications. 2007 Nov-Dec;21(6):353-8.
  12. Shen J, Cao Y, Han YJ, Luo XR, Xie CH, Li JM, Xue YM. Sweat function evaluation for early diagnosis of diabetic peripheral neuropathy. Nan Fang Yi Ke Da Xue Xue Bao. 2007 Aug;27(8):1210-2. Chinese.
  13. Eckhard M, Lengler A, Liersch J, Bretzel RG, Mayser P. Fungal foot infections in patients with diabetes mellitus–results of two independent investigations. Mycoses. 2007;50 Suppl 2:14-9.
  14. Jirkovská A, Boucek P. Examination of tactile disorders in diabetic patients and cooperation with a neurologist. Vnitr Lek. 2007 May;53(5):489-94. Review. Czech.
  15. Papanas N, Papatheodorou K, Papazoglou D, Christakidis D, Monastiriotis C, Maltezos E. The new indicator test (Neuropad): a valuable diagnostic tool for small-fiber impairment in patients with type 2 diabetes. Diabetes Educ. 2007 Mar-Apr;33(2):257-8, 260, 262 passim.
  16. Papanas N, Giassakis G, Papatheodorou K, Papazoglou D, Monastiriotis C, Christakidis D, Piperidou H, Maltezos E. Use of the new indicator test (Neuropad) for the assessment of the staged severity of neuropathy in type 2 diabetic patients. Exp Clin Endocrinol Diabetes. 2007 Jan;115(1):58-61.
  17. Papanas N, Papatheodorou K, Papazoglou D, Christakidis D, Monastiriotis C, Maltezos E. Reproducibility of the new indicator test for sudomotor function (Neuropad) in patients with type 2 diabetes mellitus: short communication. Exp Clin Endocrinol Diabetes. 2005 Dec;113(10):577-81.
  18. Papanas N, Papatheodorou K, Christakidis D, Papazoglou D, Giassakis G, Piperidou H, Monastiriotis C, Maltezos E. Evaluation of a new indicator test for sudomotor function (Neuropad) in the diagnosis of peripheral neuropathy in type 2 diabetic patients. Exp Clin Endocrinol Diabetes. 2005 Apr;113(4):195-8.
  19. Fernández-Torres R, Ruiz-Muñoz M, Pérez-Panero AJ, García-Romero J, Gónzalez-Sánchez M. Instruments of Choice for Assessment and Monitoring Diabetic Foot: A Systematic Review. J Clin Med. 2020 Feb 24;9(2):602.
  20. Burgess J, Frank B, Marshall A et al. Early Detection of Diabetic Peripheral Neuropathy: A Focus on Small Nerve Fibres. Diagnostics 2021, 11, 165.
  21. Zografou I, Iliadis F, Sambanis C, Didangelos T. Validation of Neuropad in the Assessment of Peripheral Diabetic Neuropathy in Patients with Diabetes Mellitus Versus the Michigan Neuropathy Screening Instrument, 10g Monofilament Application and Biothesiometer Measurement. Curr Vasc Pharmacol. 2020;18(5):517-522. doi: 10.2174/1570161117666190723155324.
  22. Rodríguez-Sánchez B, L. Peña-Longobardo M, Sinclair A J. Cost-effectiveness analysis of the Neuropad
    device as a screening tool for early diabetic peripheral neuropathy. Eur J Health Econ DOI 10.1007/s10198-019-01134-2
  23. Panagoulias GS, Eleftheriadou I, Papanas N, et al. Dryness of Foot Skin Assessed by the Visual Indicator Test and Risk of Diabetic Foot Ulceration: A Prospective Observational Study. Front. Endocrinol. Published online 08 September 2020
  24. Sanz-Corbalán I, Lázaro-Martínez JL, García-Morales E, et al. Advantages of early diagnosis of diabetic neuropathy in the prevention of diabetic foot ulcers. Diabetes Res Clin Pract. 2018;146:148–154.