April 2025

Purpose This study, undertaken by the Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China, aimed to evaluate how metabolic indicators impact plantar sudomotor function. It also investigated the associations between both metabolic and non-metabolic factors and sudomotor function using the Neuropad test. Methods A total of 481 adult participants were enrolled and stratified into four groups based on blood glucose levels: normoglycaemia, prediabetes, newly diagnosed diabetes, and previously diagnosed diabetes. Sudomotor function was assessed using the Neuropad, which provides both qualitative and quantitative data on sweat gland activity....

The phrase "prevention is better than cure" remains largely unfulfilled in the UK, despite government efforts to shift the NHS focus from treatment to prevention. The Wanless review, commissioned in 2002, emphasized health improvement as essential for reducing NHS demand, yet progress has stagnated, with life expectancy declining for many. To make prevention a reality, action is crucial, especially as chronic illnesses rise, leading to economic inactivity and avoidable deaths. The UK spends £100 billion annually on obesity, disproportionately affecting poorer communities, highlighting a failure in social justice. Preventive measures in nutrition,...

A recent study has identified that the sodium-glucose cotransporter 2 inhibitor dapagliflozin, a medicine used to treat type 2 diabetes, can help to regenerate small nerve fibre and so reduce or reverse the impacts of diabetic peripheral neuropathy. This study reinforces the benefits of early detection of small nerve fibre degeneration using Neuropad®, as breakthrough technologies make nerve regeneration a possibility. Overall, this is an important study that highlights a potential neuroprotective effect of SGLT2i therapy and supports the need for larger, double-blind, and longer-term trials. About the study Aims To evaluate the effect...